alcoholic fatty liver, liver poisoning. 2015;20(3):3549-3564.25706757 Milk thistle has some estrogen-like effects that may stimulate the flow of breast milk in women who are breast-feeding infants. In Hep3B cells, the protein level of G2-M regulators was reduced. Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been widely used to treat various diseases, especially hepatic diseases. Antioxidants are thought to protect body cells from damage caused by a chemical process called oxidation. These results confirmed the biological efficacy of Milk Thistle that could help in the treatment of hepatocellular carcinoma. It can be used to treat viral hepatitis caused due to hepatitis A, B, and C viruses. Antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, immunostimulating, possibly estrogenic. The effect of Silibinin on the growth, apoptosis, cytotoxicity, and cell cycle progression was examined in two HCC cell lines, Hep3B (hepatitis B virus positive with p53 mutated) and HepG2 (hepatitis B virus negative with p53 intact). It has been used for thousands of years for the treatment of liver problems. The milk thistle extract consists of 20 to 35% of fatty acids including linoleic acid. The results of this study showed a statistically significant difference in the mean ALT and AST levels before and after the treatment. It was found that Silymarin obtained from Milk Thistle could improve the liver functions in the patients infected with the hepatitis C virus. Figure 1. It acts as a cholagogue agent and increases the flow of bile from the gallbladder. Milk thistle (Silybum marianum L. Secondary effects? The cell cycle effect of Silibinin was assessed by in-bead kinase and immunoblotting assays at the molecular level. RFI Media Ltd | Please do not copy our content without permission | Website by Hallnet. But the benefits, if any, are small. It can also be used to reduce the risk of melanoma, which is a form of skin cancer. 250 ml). The active complex of this herb is a lipophilic extract obtained from the seeds of the plant. The seeds and fruits of SM contain a flavonolignan complex called silymarin, the active compounds of which include silybin, isosilybin, silychristin, dihydrosilybin, silydianin, and so on. Mediterranean region. Below we explain what this plant is, its uses, benefits, and side effects and contraindications that exist concerning its dosage. The study was focused on investigating the usefulness of Milk Thistle in the management of hepatocellular carcinoma. It is one of the oldest herb and has proved its uses and benefits in treating numerous disorders. Holarrhena Antidysenterica (Pubescens) – Kurchi (Kutaj), Amazing Benefits of Fennel Seeds (Saunf) that You Should Know, Yarsagumba (Cordyceps Sinensis – Ophiocordyceps Sinensis). It can also prevent the multiplication of the abnormal cancer cells. Milk thistle, or silybum marianum, has been used as a herbal healer since ancient Greek times. This helps to reduce their risk of alcoholic hepatitis. You can use this supplement to improve overall health. Silymarin marianum is a plant whose many components, primarily a flavanolignan chemical known as silymarin, have pronounced antioxidant and skin-calming ability. It is often referred to as end-stage liver disease. There is insufficient evidence to support the use of milk thistle for any of the below listed uses. This herb is a must for cleansing and for anyone with any sort of liver dysfunction or exposure to toxins. Topical preparations of milk thistle extract is quite beneficial the skin. This substance, which actually consists of a group of compounds called flavonolignans, helps repair liver cells damaged by alcohol and other toxic substances by stimulating protein synthesis. For Ptolemy's town of Corsica, see Bonifacio, for the plant S. marianum, see Silybum marianum. Milk thistle, known as 'Doodh Patra' has medicinal properties. Blessed milk thistle,Cardui mariae, Carduus marianum, Holy Thistle, Lady's Thistle, Legalon, Marian Thistle, Mariendistel, Mary Thistle, Mediterranean milk thistle, Our Lady's Thistle, Silimarina, Silybin, Silybum, Silymarin, St. Mary Thistle, Wild Artichoke, variegated thistle and Scotch thistle. Milk thistle might lower blood sugar in people who have type 2 diabetes, but more studies are needed to confirm its benefits. Ethnopharmacological relevance: Silybum marianum (L.) Gaertn. W lecznictwie wykorzystuje się owoce tej rośliny. Gaertn.) Milk Thistle Benefits for Dogs ... Silybin, and Silydianin, which is collectively known as Silybum marianum. A European standardized extract of milk thistle was used in most of the trials. It contains a chemical called silymarin. The extract of this herb is used to reap its cell regenerating benefits. It acts as a powerful detoxifier and helps to rebuild the liver cells. It has been observed to relieve acid reflux, nausea and/or vomiting. But the benefits, if any, are small. Silybum marianum is by far the more widely known species. Milk thistle can reduce the effect of toxins and alcohol on the liver. It also helps to inhibit the free radical chain reaction mechanism. Read more about the prescription drug MILK THISTLE (Silybum marianum) - ORAL. More About Milk Thistle Silybum marianum) jest rośliną pochodzącą z rejonu Morza Śródziemnego. The scar tissue reduces the ability of the liver to function optimally and makes the organ hard and lumpy. It also helps to inhibit the free radical chain reaction mechanism. Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect.It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power. A native plant to Southern Europe, the Middle East, and Asia, milk thistle is derived from compounds found in Silybum marianum, a plant that’s in the same family as sunflowers and daisies. Silybum marianum, commonly known as Milk thistle or St Mary’s thistle, is a herbal remedy that is commonly used to support liver health. Due to these components, milk thistle has anti-inflammatory properties, and it helps treat liver diseases in dogs, cats, ferrets, and even humans. Milk Thistle can also be used as an adjuvant treatment along with the use of chemotherapeutic agents. Mediterranean regions, Meadows, Borders of forests. Nie należy przekraczać zalecanej porcji do spożycia w ciągu dnia. Milk thistle contains several phytochemicals such as flavonolignans, silybinin, silymarin, isosilibinin, betaine, silymarin, silychristin, and silydianin. [where?] Milk thistle was approved in 1986 as a treatment for liver disease and it is widely used to treat alcoholic hepatitis, alcoholic fatty liver, cirrhosis, liver poisoning and viral hepatitis. These actions of Milk Thistle help in preventing the progress of cirrhosis. viral hepatitis ) and the extract, silymarin , is used in medicine. The left figures (A,C,E) describe measurements of plants grown under normal conditions (20°/10°C d/n). Milk thistle was less effective for those with severe liver disease such as cirrhosis. This species is an annual or biennial plant of the family Asteraceae. The use of this herb is recommended for the patients suffering from cancer. It also offers a rich source of flavonoids. 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